5 things to know about transgender depersonalization

“…I was a dispassionate observer of my own life. The person who went through the motions wasn’t the observer-me. Whenever the acting-me felt any emotions, the observer-me recognized the emotions but didn’t feel them herself.”


Chronic depersonalization is a distressing dissociative condition characterized by feelings of “unreality” or “no self”, and it occurs at an elevated rate among trans people. Also known as depersonalization disorder or depersonalization-derealization syndrome, sufferers of this condition perceive themselves as emotionally distanced and separated from their experience of self and their perception of the world [1]. While their grasp of reality is intact, they perceive themselves as not truly feeling their own emotions, and have a sense that the world is flat, lifeless, or lacking in meaning or depth. Depersonalization disorder is chronic and unremitting; most individuals experience its onset in adolescence, while others report it being present since their childhood [2]. Studies have found that trans people are anywhere from 3 to 18 times more likely to experience this chronic syndrome compared to the general population [3], and depersonalization has been a theme of numerous personal accounts and memoirs of trans people for decades [4, 5].

Those with depersonalization often experience their self as separated into an outer participant in the world and a detached and emotionless inner observer, and they can feel that a kind of “veil”, “fog” or “glass” has interposed itself between them and the world around them. They may find spontaneity to be difficult or elusive – with little sense of agency or investment in life, they often feel that they are a “robot” or a “zombie” who is simply “going through the motions” [6]. Sufferers may also ruminate or obsess over existential questions about reality and the self. Despite their experience of emotional numbing, those with depersonalization typically find this to be a “painful absence of feeling” and a highly distressing condition [7]. The elevated prevalence of these serious symptoms among trans people make depersonalization an item of special concern to us.


Chronic depersonalization is not just depression or anxiety. Because depersonalization alters the texture and sensation of subjective experience on a very deep and even pre-verbal level, sufferers often find it challenging to explain or convey these symptoms to others; living with depersonalization disorder has long been recognized as notoriously difficult to describe in any way other than metaphor [8]. While inexperienced clinicians may misdiagnose the chronic syndrome of depersonalization as instead being symptoms of depression or anxiety alone, studies have found that depersonalization disorder represents a symptom cluster distinct from depression or anxiety [9].


Chronic depersonalization can have a severe and wide-ranging impact on mental health and well-being. The distressing experience of unremitting depersonalization is typically not an innocuous or harmless syndrome. Individuals with depersonalization disorder are more likely to experience comorbid mental health conditions, such as depressive disorders, anxiety disorders, suicidal ideation and attempts, and avoidant personality disorder [10]. As a result of these interlocking struggles, sufferers can face difficulties and impairments in employment, personal relationships, academic achievement, independent living, positive coping strategies, cognitive function and focus, and overall social engagement [11].


Depersonalization symptoms can be successfully treated via transition, particularly hormone therapy. Clinical studies repeatedly find that trans people who’ve medically transitioned have decreased rates of chronic depersonalization and its symptoms, similar to the general population [12]. Much as hormone therapy has been found to have a positive effect on depressive and anxious symptoms in trans people, HRT is also associated with a measurable reduction in depersonalization among both trans women and trans men [13].


Trans people can benefit from greater awareness and screening for depersonalization. Existing guidelines recommend that providers assess trans people seeking transition care for co-occurring mental health conditions [14, 15]. Unfortunately, even among the general population, depersonalization disorder is “poorly recognised and under-treated” [16], and there is “a dramatic neglect of DP in clinical routine” [9]. It is typical for sufferers to experience the symptoms of chronic depersonalization for 7–12 years before receiving a diagnosis, and some have lived with this for half of their lifetime [17]; they may even have had depersonalization for so long that they’ve become “habituated to it as ‘normal'” [6]. Those with depersonalization can find relief in simply knowing that their symptoms have a name and are part of a recognized condition, and that they are not alone in this experience [16].

Given the potentially severe impact of untreated depersonalization on mental health, recognition of these symptoms among trans people is of urgent importance. When considering their medical options, trans people should be aware that transition may provide relief from depersonalization, and that those struggling with this condition may benefit from additional medications or psychotherapy focused on these symptoms [17]. Emergence from the fog of depersonalization can be a highly rewarding and life-enriching experience for trans people, with many reporting a sense of feeling truly alive for the first time and a transformative improvement in their ability to be engaged with the world around them. By being aware of these symptoms in trans people, healthcare providers can play a key role in helping us become our fullest selves. 

Support Gender Analysis on Patreon


About Zinnia Jones

My work focuses on insights to be found across transgender sociology, public health, psychiatry, history of medicine, cognitive science, the social processes of science, transgender feminism, and human rights, taking an analytic approach that intersects these many perspectives and is guided by the lived experiences of transgender people. I live in Orlando with my family, and work mainly in technical writing.
This entry was posted in Depersonalization, Gender dysphoria, Health care, Psychology and psychiatry, Transgender medicine and tagged , , . Bookmark the permalink.

One Response to 5 things to know about transgender depersonalization

  1. OfLiliesAndRemains says:

    I’ve read everything on your site concerning depersonalisation with great interest so far and have had many positive experiences talking with others about it. I think this article is missing something very significant though. With me personally, and though i might be biased i think i seem to read this in several of the testimonials a well, the existence of my depersonalisation made it harder for me to come to grips with being trans as it took the bite out of my dysphoria. I hardly felt anything at all, but i thought that was just me. It actually wasn’t until i found your article on the less obvious signs of dysphoria that i started to realize the actual extent of my dysphoria (thank you so much by the way, i think it literally saved me years of therapy). Keep up the good work! I’m pretty sure you’re saving lives over here.

Leave a Reply

Your email address will not be published. Required fields are marked *