Category Archives: Biology of transition

Migraine headaches, trans people, and hormone therapy

From age 3 or 4, which is as far back as I can remember, I experienced chronic, frequent migraine headaches, just as my mother and her father have had throughout their lives. These episodes of severe pain would often happen … Continue reading

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New study of the effects of feminizing hormones on testicular tissue in trans women

Most trans women on HRT are familiar with the phenomenon of “shrinkage”: atrophy of penile and testicular tissue, which typically becomes more pronounced the longer we’re on hormones. I’ve always wondered, as have many others, just what’s happening on the … Continue reading

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New clinical findings from Dr. Will Powers: Role of estradiol/estrone ratio in the efficacy of feminizing HRT

(Epistemic status: Extremely tentative.) Dr. Will Powers, an HRT provider in Michigan who has possibly the coolest name ever, has recently posted a slideshow outlining findings from his practice on the most effective approaches to feminizing hormone therapy for trans … Continue reading

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Your mileage may vary: Trans women and erectile function

One common question asked by trans women considering hormone therapy is how this may affect their ability to have penetrative sex. Antiandrogens and estrogen can impair erectile function, reducing spontaneous erections, responsiveness to sexual arousal, and nocturnal erections — an … Continue reading

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Fractals, not pyramids: Why “8th grade biology” isn’t enough

Previously: Chromosomes: Cis expectations vs. trans reality, How sex hormones work, and their use by trans people In the years I’ve spent covering gender topics on YouTube, I’ve occasionally encountered one particularly strange objection to the core principle of transness, … Continue reading

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