Category Archives: Endocrinology

New clinical findings from Dr. Will Powers: Role of estradiol/estrone ratio in the efficacy of feminizing HRT

(Epistemic status: Extremely tentative.) Dr. Will Powers, an HRT provider in Michigan who has possibly the coolest name ever, has recently posted a slideshow outlining findings from his practice on the most effective approaches to feminizing hormone therapy for trans … Continue reading

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New study: Hormone therapy appears to be safe in trans youth

It’s common to encounter uninformed claims online about the supposed toxicity, carcinogenicity, or outsized health risks of medical treatment for trans people, such as puberty blockers and hormone therapy. While such claims are almost universally unsubstantiated, positive evidence for the … Continue reading

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Your mileage may vary: Trans women and erectile function

One common question asked by trans women considering hormone therapy is how this may affect their ability to have penetrative sex. Antiandrogens and estrogen can impair erectile function, reducing spontaneous erections, responsiveness to sexual arousal, and nocturnal erections — an … Continue reading

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Cyproterone acetate and meningioma risk in trans women

Disclaimer: I am not a doctor, and this is not medical advice. Do not take any medication without appropriate medical supervision. Cyproterone acetate (CPA) is a hormonal medication commonly used as an antiandrogen for trans women, as well as in … Continue reading

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Bicalutamide, a new anti-androgen for trans women and girls

Disclaimer: I am not a doctor, and this is not medical advice. Do not take any medication without appropriate medical supervision. Previously I’ve looked at low-cost alternatives to GnRH analogue puberty blockers for trans adolescents, including medroxyprogesterone acetate, spironolactone, cyproterone … Continue reading

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