Category Archives: Endocrinology

Nifty finds: Super-fast-acting hormone blockers used in Sweden

GnRH agonists are a class of drugs sometimes used as part of medical transition for trans people in order to block the sex hormones produced by their own bodies (Hembree et al., 2017). These are long-acting medications, typically given as … Continue reading

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Trans women with BRCA mutations: options for hormone therapy

The risk of breast cancer is a concern for trans women transitioning using estrogen and anti-androgens: they experience the growth of substantial breast tissue just as cis women do, and the use of estrogen could promote the growth of any … Continue reading

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New clinical findings from Dr. Will Powers: Role of estradiol/estrone ratio in the efficacy of feminizing HRT

(Epistemic status: Extremely tentative.) Dr. Will Powers, an HRT provider in Michigan who has possibly the coolest name ever, has recently posted a slideshow outlining findings from his practice on the most effective approaches to feminizing hormone therapy for trans … Continue reading

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New study: Hormone therapy appears to be safe in trans youth

It’s common to encounter uninformed claims online about the supposed toxicity, carcinogenicity, or outsized health risks of medical treatment for trans people, such as puberty blockers and hormone therapy. While such claims are almost universally unsubstantiated, positive evidence for the … Continue reading

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Your mileage may vary: Trans women and erectile function

One common question asked by trans women considering hormone therapy is how this may affect their ability to have penetrative sex. Antiandrogens and estrogen can impair erectile function, reducing spontaneous erections, responsiveness to sexual arousal, and nocturnal erections — an … Continue reading

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